Sabialimon P
Sabialimon P (compound 16) is a NO release inhibitor (IC50=18.12 μM) with anti-inflammatory activity. Sabialimon P significantly reduces the secretion of TNF-α, iNOS, IL-6 and NF-κB and inhibits the expression of COX-2 and NF-κB/p65 in RAW264.7 cells induced by LPS.
Product Specifications
CAS Number
2267333-96-8
UNSPSC
12352005
Target
COX; Interleukin Related; NF-κB; NO Synthase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sabialimon-p.html
Smiles
COC([C@]12[C@](CC(C)(CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](C[C@@H]4O)O)C)([H])CC5)C)([H])[C@]5(C)[C@@]3(CC1)C)=O
Molecular Formula
C31H50O4
Molecular Weight
486.73
References & Citations
[1]Yan Huang, et al. "Oleanane-type triterpenoids from Sabia limoniacea and their anti-inflammatory activities." Bioorganic Chemistry (2024) : 107683.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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