4-Hydroxyatomoxetine

4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6) . Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively) [1][2].

Product Specifications

CAS Number

[435293-66-6]

UNSPSC

12352005

Hazard Statement

H302-H319-H361

Target

Adrenergic Receptor; Drug Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxyatomoxetine.html

Purity

97.04

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1

Molecular Formula

C17H21NO2

Molecular Weight

271.36

Precautions

P264-P270-P280-P305+P351+P338-P330-P405-P501

References & Citations

[1]JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children.|[2]Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27 (5) :699-711.