Cemadotin (hydrochloride)
Product Specifications
UNSPSC Description
Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer[1][2].
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cemadotin-hydrochloride.html
Smiles
CC(C)[C@H](N(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC3=CC=CC=C3)=O)=O)=O)=O)=O.Cl
Molecular Weight
677.32
References & Citations
[1]Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37(50):17571-8.|[2]Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):941-4.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13589A/Cemadotin-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13589A/
Clinical Information
No Development Reported
CAS Number
172837-41-1
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