Cemadotin (hydrochloride)

Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer[1][2].

Product Specifications

CAS Number

[172837-41-1]

Product Name Alternative

LU103793 (hydrochloride)

UNSPSC

12352209

Target

Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cemadotin-hydrochloride.html

Smiles

CC(C)[C@H](N(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC3=CC=CC=C3)=O)=O)=O)=O)=O.Cl

Molecular Formula

C35H57ClN6O5

Molecular Weight

677.32

References & Citations

[1]Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37 (50) :17571-8.|[2]Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51 (4) :941-4.