Pelacarsen
Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a) [1][2][3].
Product Specifications
CAS Number
[1637637-70-7]
Product Name Alternative
AKCEA-APO (a) -LRx; ISIS 681257; TQJ230
UNSPSC
12352208
Target
Apolipoprotein; DNA/RNA Synthesis
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pelacarsen.html
Purity
92.70
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Pelacarsen]
Molecular Formula
C296H439N71O163P20S13
Molecular Weight
8636.00
References & Citations
[1]Yeang C, et al. Effect of Pelacarsen on Lipoprotein (a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 Mar 22;79 (11) :1035-1046. |[2]Yu RZ, Graham MJ, Post N, et al. Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice. Mol Ther Nucleic Acids. 2016;5 (5) :e317. |[3]Yu RZ, Gunawan R, Post N, et al. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys. Nucleic Acid Ther. 2016;26 (6) :372-380.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Curated Selection
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