C3N-Dbn-Trp2
C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 efflux in cells HEK293T and HCT-15 with IC50 of 5.9 µM and 2.2 µM. C3N-Dbn-Trp2 inhibits the Doxorubicin (HY-15142A) efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells[1].
Product Specifications
CAS Number
2631659-57-7
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c3n-dbn-trp2.html
Smiles
[H][C@@]12N(CC3=CC=CC=C3)C4=CC=CC=C4[C@]1(CC5=CC=CC=C5)C[C@]6([H])N2C([C@@](CC7=CNC8=C7C=CC=C8)([H])NC6=O)=O
Molecular Formula
C36H32N4O2
Molecular Weight
552.66
References & Citations
[1]Koh JYP, et al., Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors. Commun Chem. 2024 Jul 13;7 (1) :158.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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