HMR 1556
HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2].
Product Specifications
CAS Number
223749-46-0
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hmr-1556.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CS(N([C@H]1C2=CC(OCCCC(F)(F)F)=CC=C2OC(C)(C)[C@@H]1O)C)(=O)=O
Molecular Formula
C17H24F3NO5S
Molecular Weight
411.44
References & Citations
[1]Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41 (1) :140-7.|[2]Gerlach U, et al. Synthesis and activity of novel and selective I (Ks) -channel blockers. J Med Chem. 2001 Nov 8;44 (23) :3831-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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