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1-Stearoyl-2-15 (S) -HETE-sn-glycero-3-PE-d11

Selected Variant

HY-145473S

Size: 1 Each

1-Stearoyl-2-15 (S) -HETE-sn-glycero-3-PE-d11 (15 (S) -HETE-SAPE-d11) is deuterium labeled 1-Stearoyl-2-15 (S) -HETE-sn-glycero-3-PE. 1-Stearoyl-2-15 (S) -HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15 (S) -HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15 (S) -HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes[1].

Product Specifications

Product Name Alternative

15 (S) -HETE-SAPE-d11; 15 (S) -Hydroxyeicosatetraenoic acid-SAPE-d11; 1-Stearoyl-2-15 (S) -HETE-sn-glycero-3-Phosphatidylethanolamine-d11

UNSPSC

12352211

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Metabolic Disease

Smiles

OP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCC/C=C\C/C=C\C/C=C\C=C\[C@H](C([2H])(C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])[2H])O)=O)(OCCN)=O

Molecular Formula

C43H67D11NO9P

Molecular Weight

795.12

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Maskrey, et al. Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase. J. Biol. Chem. 282 (28), 20151-20163 (2007) .

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Price

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