IMPDH2-IN-4
IMPDH2-IN-4 (compound 2d), a Mycophenolic acid analogue, is a selective IMPDH2 inhibitor with a Ki of 1.8 μM. IMPDH2-IN-4 exhibits good cytotoxic activity against osteosarcoma cancer cell lines. IMPDH2-IN-4 possesses a high affinity for VEGFR-2, CDK2, and IMPDH[1].
Product Specifications
UNSPSC
12352005
Target
CDK; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/impdh2-in-4.html
Smiles
O=C(O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CC/C(C)=C/CC4=C(O)C5=C(COC5=O)C(C)=C4OC
Molecular Formula
C35H34O6Si
Molecular Weight
578.73
References & Citations
[1]Patamawadee Silalai, et al. Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment. ACS Bio Med Chem Au, October 17, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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