A-74273
A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM) . A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension[1][2].
Product Specifications
CAS Number
130316-95-9
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/a-74273.html
Smiles
CCCC[C@H](O[C@H](C(N1CCC(OCOC)CC1)=O)CC2=CC=CC=C2)C(NC(C(O)C[C@H](C(NCCCN3CCOCC3)=O)C(C)C)CC4CCCCC4)=O
Molecular Formula
C44H74N4O8
Molecular Weight
787.08
References & Citations
[1]Dayton, et al. Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors. Clinical chemistry 38.11 (1992) : 2239-2243.|[2]Kleinert, et al. "Discovery of a well-absorbed, efficacious renin inhibitor, A-74273." Hypertension 20.6 (1992) : 768-775.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSM040649 100 µg
Recombinant Mouse TNFR1/TNFRSF1A Protein (Fc Tag)
Sign In for Pricing
View Details 
![iNOS (NOS2) Mouse Monoclonal Antibody [Clone ID: OTI11H3]](https://cdn.genprice.uk/products/937/68dd1b88061270361ea21427/imageurl/ta813520.webp)
TA813520 100 µL
iNOS (NOS2) Mouse Monoclonal Antibody [Clone ID: OTI11H3]
Sign In for Pricing
View Details