Stauprimide

Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation. Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which results in down-regulation of MYC transcription[1].

Product Specifications

CAS Number

[154589-96-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; c-Myc

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stauprimide.html

Purity

99.45

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

C[C@@]([C@@H]1OC)(O[C@](N2C3=CC=CC=C43)([H])C[C@H]1N(C)C(C5=CC=CC=C5)=O)N6C(C2=C4C(C7=O)=C8C(N7)=O)=C8C9=C6C=CC=C9

Molecular Formula

C35H28N4O5

Molecular Weight

584.62

Precautions

H315, H319, H335

References & Citations

[1]Bouvard C, et al. Small molecule selectively suppresses MYC transcription in cancer cells. Proc Natl Acad Sci USA. 2017 Mar 28;114 (13) :3497-3502.