Lexacalcitol

Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].

Product Specifications

CAS Number

[131875-08-6]

Product Name Alternative

KH1060

UNSPSC

12352211

Hazard Statement

H300

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Lexacalcitol.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]1(CCC/2)[C@](CC[C@@H]1[C@@H](C)OCCCC(CC)(CC)O)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C

Molecular Formula

C29H48O4

Molecular Weight

460.69

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42 (8) :1569-75.|[2]C Gysemans, et al. A combination of KH1060, a vitamin D (3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33 (3) :2365.