Antibacterial agent 218

Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Endogenous Metabolite; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-218.html

Smiles

CN1C(C)=C(C(N1C2=CC=CC=C2)=O)N3/C(SC=C3C4=CC5=C(C=C4)C=CC=C5)=N/C6=CC=CC=C6

Molecular Formula

C30H24N4OS

Molecular Weight

488.60

References & Citations

[1]Wang X, et al. Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections. J Med Chem. 2024;67 (11) :9318-9341.