Vilazodone-d8 (hydrochloride)

Vilazodone-d8 hydrochloride is deuterated labeled Vilazodone (HY-14262) . Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders[1][2].

Product Specifications

Product Name Alternative

EMD 68843-d8; SB659746A-d8

UNSPSC

12352005

Target

5-HT Receptor; Isotope-Labeled Compounds; Serotonin Transporter

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

NC(C1=CC2=C(C=CC(N3CCN(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C4=CNC5=CC=C(C=C54)C#N)CC3)=C2)O1)=O.Cl

Molecular Formula

C26H20D8ClN5O2

Molecular Weight

486.04

References & Citations

[1]Cruz MP. Vilazodone HCl (Viibryd) : A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37 (1) :28-31.|[2]Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.