CP-466722
CP-466722 is a rapidly reversible inhibitor of ATM, with an IC50 of 0.41 μM, and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.
Product Specifications
CAS Number
1080622-86-1
UNSPSC
12352005
Hazard Statement
H302
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CP-466722.html
Purity
99.74
Solubility
DMSO : 1 mg/mL (ultrasonic)
Smiles
NC1=NC(C2=NC=CC=C2)=NN1C3=C4C=C(OC)C(OC)=CC4=NC=N3
Molecular Formula
C17H15N7O2
Molecular Weight
349.35
Precautions
H302
References & Citations
[1]Rainey MD, et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68 (18) :7466-74.|[2]Guo K, et al. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen. 2014 Apr;19 (4) :538-46.|[3]W?sierska-G?dek J, et al. Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly (ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. J Cancer Prev. 2014 Jun;19 (2) :125-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
Available Sizes
Frequently Asked Questions
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