Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

CP-466722

CP-466722 is a rapidly reversible inhibitor of ATM, with an IC50 of 0.41 μM, and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.

Product Specifications

CAS Number

1080622-86-1

UNSPSC

12352005

Hazard Statement

H302

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CP-466722.html

Purity

99.74

Solubility

DMSO : 1 mg/mL (ultrasonic)

Smiles

NC1=NC(C2=NC=CC=C2)=NN1C3=C4C=C(OC)C(OC)=CC4=NC=N3

Molecular Formula

C17H15N7O2

Molecular Weight

349.35

Precautions

H302

References & Citations

[1]Rainey MD, et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68 (18) :7466-74.|[2]Guo K, et al. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen. 2014 Apr;19 (4) :538-46.|[3]W?sierska-G?dek J, et al. Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly (ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. J Cancer Prev. 2014 Jun;19 (2) :125-36.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ATM

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Benchtop Low Speed Refrigerated Centrifuge BCBLR-201
BCBLR-201 1 Unit

Benchtop Low Speed Refrigerated Centrifuge BCBLR-201

Sign In for Pricing
View Details
Xamoterol Hemifumarate
TRC-X499808-10MG 10 mg

Xamoterol Hemifumarate

Sign In for Pricing
View Details
Fmoc-Ala Wang Resin LL
HLL0751501301.25G 25 g

Fmoc-Ala Wang Resin LL

Sign In for Pricing
View Details
KCNJ12 Mouse Monoclonal Antibody [Clone ID: N124B/38]
75-203 100 µL

KCNJ12 Mouse Monoclonal Antibody [Clone ID: N124B/38]

Sign In for Pricing
View Details
TRP1 (Tyrosinase Related Protein 1) (TYRP1/807), CF594 conjugate, 0.1mg/mL
BNC940807-500 1x 500 µL

TRP1 (Tyrosinase Related Protein 1) (TYRP1/807), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
LOC401052 Human Gene Knockout Kit (CRISPR)
KN415358 1 Kit

LOC401052 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details