Tipifarnib (S enantiomer)
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
Product Specifications
CAS Number
[192185-71-0]
Product Name Alternative
IND-58359 S enantiomer; (S) - (-) -R-115777
UNSPSC
12352005
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tipifarnib-S-enantiomer.html
Concentration
10mM
Purity
99.52
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1N(C)C2=C(C=C([C@](C3=CC=C(Cl)C=C3)(N)C4=CN=CN4C)C=C2)C(C5=CC=CC(Cl)=C5)=C1
Molecular Formula
C27H22Cl2N4O
Molecular Weight
489.40
References & Citations
[1]Kraus JM, et al. Rational modification of a candidate cancer drug for use against Chagas disease. J Med Chem. 2009 Mar 26;52 (6) :1639-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
Bovine Olfactory receptor 1L3 (OR1L3) ELISA Kit
Recombinant Clostridium Perfringens CPE0046 Protein (aa 1-112)