AJ2-30

AJ2-30 is a SLCl5A4 inhibitor. AJ2-30 inhibits endolysosomal TLR7-9-mediated mTOR activation. AJ2-30 blocks endogenous NOD signaling. AJ2-30 can be used in inflammation studies[1][2].

Product Specifications

CAS Number

[2700322-79-6]

UNSPSC

12352005

Target

MTOR; NOD-like Receptor (NLR) ; Oligopeptide Cotransporter

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aj2-30.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCN1C2=C(C=CC=C2)C3=CC(CNC4=NC5=C(N4C)C=CC=C5)=CC=C31

Molecular Formula

C23H22N4

Molecular Weight

354.45

References & Citations

[1]Daniel Lazar, et al. Small molecule inhibitors of scl15a4 with anti-inflammatory activity. Patent. WO2021174023.|[2]Chiu TY, et al. Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. Nat Chem Biol. 2024 Aug;20 (8) :1000-1011.