S 32212 hydrochloride

S 32212 hydrochloride is an inverse agonist of 5-HT receptors 5-HT2 (CINI) and 5-HT2 (CVSV) (Kis=6.6, 8.9 nM) and an antagonist of 5-HT2A and α2β-adrenergic receptors (Ki=5.8, 5.8 nM) . S 32212 hydrochloride can reduce the binding of GTPγS to Gαq, and reduce the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2 (CINI) receptor and CHO cells expressing 5-HT2 (CVSV) receptor (EC50=38 and 18.6 nM, respectively) . S 32212 hydrochloride (2.5 mg/kg) reduces 5-HT receptor agonist-induced head twitches and penile erections in mice and rats. S 32212 hydrochloride (10, 40 mg/kg) reduces immobility time in the forced swim test and marble burying behavior in mice and rats, exerting antidepressant and anxiolytic activities.

Product Specifications

CAS Number

[847871-78-7]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-32212-hydrochloride.html

Smiles

O=C(N1CCC2=C1C=CC3=CC=CC=C23)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl

Molecular Formula

C25H29ClN4O2

Molecular Weight

452.98

References & Citations

[1]Millan, et al. S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization. J. Pharmacol. Exp. Ther. 340 (3), 750-764 (2012) .