Ro 8-4304

Ro 8-4304 is a non-competitive, voltage-independent and state-dependent antagonist for NMDA receptor. Ro 8-4304 inhibits 10 μM NMDA-induced currents and 100 μM NMDA-induced currents with IC50s of 2.3 μM and 0.36 μM[1].

Product Specifications

CAS Number

[195988-65-9]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ro-8-4304.html

Smiles

O=C(C1=CC=C(C=C1)OCC(CN2CC=C(CC2)C3=CC=C(F)C=C3)O)N

Molecular Formula

C21H23FN2O3

Molecular Weight

370.42

References & Citations

[1]Kew JN, et al., State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br J Pharmacol. 1998 Feb;123 (3) :463-72.