Ro 8-4304
Ro 8-4304 is a non-competitive, voltage-independent and state-dependent antagonist for NMDA receptor. Ro 8-4304 inhibits 10 μM NMDA-induced currents and 100 μM NMDA-induced currents with IC50s of 2.3 μM and 0.36 μM[1].
Product Specifications
CAS Number
195988-65-9
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ro-8-4304.html
Smiles
O=C(C1=CC=C(C=C1)OCC(CN2CC=C(CC2)C3=CC=C(F)C=C3)O)N
Molecular Formula
C21H23FN2O3
Molecular Weight
370.42
References & Citations
[1]Kew JN, et al., State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br J Pharmacol. 1998 Feb;123 (3) :463-72.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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