NCI126224
Product Specifications
UNSPSC Description
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].
Target Antigen
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nci126224.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(/C(C(OC)=O)=C\C1=C([N+]([O-])=O)C=CC=C1)OC
Molecular Weight
265.22
References & Citations
[1]Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156060/NCI126224-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156060/NCI126224-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
65974-52-9
Available Sizes
Curated Selection
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