NCI126224
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056) -induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].
Product Specifications
CAS Number
[65974-52-9]
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nci126224.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(/C(C(OC)=O)=C\C1=C([N+]([O-])=O)C=CC=C1)OC
Molecular Formula
C12H11NO6
Molecular Weight
265.22
References & Citations
[1]Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20 (20) :6073-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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