NCI126224

NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056) -induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].

Product Specifications

CAS Number

[65974-52-9]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nci126224.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(/C(C(OC)=O)=C\C1=C([N+]([O-])=O)C=CC=C1)OC

Molecular Formula

C12H11NO6

Molecular Weight

265.22

References & Citations

[1]Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20 (20) :6073-9.