DW18134
DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides (HY-D1056) -induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function [1].
Product Specifications
CAS Number
[2626988-87-0]
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dw18134.html
Solubility
10 mM in DMSO
Smiles
CC(O1)(C)CC2=C1C=C(C3=CC=NC=C3)C(NC(C4=COC(C5=CC(N)=NC=C5)=N4)=O)=C2
Molecular Formula
C24H21N5O3
Molecular Weight
427.46
References & Citations
[1]Huang Y, et al., A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease. Molecules. 2024 Apr 16;29 (8) :1803.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
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