Cytochalasin J

Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC50 of 1.5 μM[1][2].

Product Specifications

CAS Number

[53760-20-6]

UNSPSC

12352005

Hazard Statement

H300-H310-H330-H351

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cytochalasin-j.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@]12[C@](/C=C/C[C@H](C)C[C@@](C)(O)/C=C/[C@H]2O)([H])[C@@H]3O)N[C@@H](CC4=CC=CC=C4)[C@]1([H])[C@H](C)C3=C

Molecular Formula

C28H37NO4

Molecular Weight

451.60

Precautions

P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Xu S, et al., Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. Chem Biodivers. 2009 May;6 (5) :739-45.|[2]Wrench GA, et al., Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells. Cell Motil Cytoskeleton. 1997;36 (2) :112-24.