Oxyphenbutazone-13C6

Oxyphenbutazone-13C6 is the 13C6 labeled Oxyphenbutazone (HY-B1355A) . Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230) . Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2].

Product Specifications

UNSPSC

12352005

Target

Bacterial; COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oxyphenbutazone-13c6.html

Solubility

10 mM in DMSO

Smiles

O=C(C1CCCC)N([13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)N(C3=CC=C(O)C=C3)C1=O

Molecular Formula

C13 13C6H20N2O3

Molecular Weight

330.33

References & Citations

[1]Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109 (40) :16004-11.|[2]Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444 (1-2) :187-196.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.