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N-Desethyl amodiaquine-d5 (dihydrochloride)

N-Desethyl amodiaquine-d5 dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

Product Specifications

CAS Number

1216894-33-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Purity

98.76

Solubility

H2O : 100 mg/mL (ultrasonic; warming)

Smiles

ClC1=CC2=C(C(NC3=CC(CNC([2H])(C([2H])([2H])[2H])[2H])=C(O)C=C3)=CC=N2)C=C1.Cl.Cl

Molecular Formula

C18H15D5Cl3N3O

Molecular Weight

405.76

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199 (11) :1575-82.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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