N-Desethyl amodiaquine-d5 (dihydrochloride)
Product Specifications
UNSPSC Description
N-Desethyl amodiaquine-d5 (dihydrochloride) is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].
Target Antigen
Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Others
Field of Research
Infection
Purity
98.76
Solubility
H2O : 100 mg/mL (ultrasonic;warming)
Smiles
ClC1=CC2=C(C(NC3=CC(CNC([2H])(C([2H])([2H])[2H])[2H])=C(O)C=C3)=CC=N2)C=C1.Cl.Cl
Molecular Weight
405.76
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Clinical Information
No Development Reported
CAS Number
1216894-33-5
Available Sizes
Curated Selection
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