STAD 2

STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism[1][2].

Product Specifications

CAS Number

[1542100-77-5]

UNSPSC

12352209

Target

PKA

Type

Peptides

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/stad-2.html

Purity

99.55

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C)C[C@H](NC([C@H](C)NC([C@]1(C)CCC/C=C/CCC[C@](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N1)=O)=O)=O)=O)(C)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC(COCCOCCOCCN)=O)=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)=O)=O)=O)C(N[C@@H](CCCCN)C(N)=O)=O

Molecular Formula

C102H182N24O22

Molecular Weight

2096.68

References & Citations

[1]Wang Y, et, al. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol. 2014 Mar 21;9 (3) :635-42.|[2]Flaherty BR, et, al. The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. PLoS One. 2015 May 26;10 (5) :e0129239.