STAD 2
STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism[1][2].
Product Specifications
CAS Number
1542100-77-5
UNSPSC
12352209
Target
PKA
Type
Peptides
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/stad-2.html
Purity
99.55
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)C[C@H](NC([C@H](C)NC([C@]1(C)CCC/C=C/CCC[C@](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N1)=O)=O)=O)=O)(C)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC(COCCOCCOCCN)=O)=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)=O)=O)=O)C(N[C@@H](CCCCN)C(N)=O)=O
Molecular Formula
C102H182N24O22
Molecular Weight
2096.68
References & Citations
[1]Wang Y, et, al. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol. 2014 Mar 21;9 (3) :635-42.|[2]Flaherty BR, et, al. The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. PLoS One. 2015 May 26;10 (5) :e0129239.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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