LLC355
LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion[1].
Product Specifications
UNSPSC
12352005
Target
ATTECs; Discoidin Domain Receptor
Type
Reference compound
Related Pathways
Autophagy; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/llc355.html
Smiles
O=C1C2=CC=C(Cl)C=C2N=C([C@H](N(C(C3=CC=C(C)C=C3)=O)CCCNC(COCCN4CCN(CC5=CC(C(F)(F)F)=CC(NC(C6=CC(C#CC(C=N7)=CN8C7=CC=N8)=C(CC)C=C6)=O)=C5)CC4)=O)C(C)C)N1CC9=CC=CC=C9
Molecular Formula
C63H64ClF3N10O5
Molecular Weight
1133.69
References & Citations
[1]Liu L, et al. Discovery of LLC355 as an Autophagy-Tethering Compound for the Degradation of Discoidin Domain Receptor 1. J Med Chem. 2024 May 23;67 (10) :8043-8059.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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