Picenadol
Picenadol (LY-150720) is an opioid mixed agonist-antagonist analgesic. Picenadol is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol has anticholinergic activity[1][2].
Product Specifications
CAS Number
79201-85-7
Product Name Alternative
LY-150720
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/picenadol.html
Solubility
10 mM in DMSO
Smiles
CCC[C@]1([C@@H](C)CN(CC1)C)C2=CC(O)=CC=C2
Molecular Formula
C16H25NO
Molecular Weight
247.38
References & Citations
[1]Carter RB, et al. Effects of LY150720 (picenadol), a novel mixed-action opioid, on schedule-controlled responding in the squirrel monkey. Pharmacol Biochem Behav. 1984 Nov;21 (5) :779-86.|[2]Zimmerman DM, et al. Picenadol. Drug Alcohol Depend. 1985 Feb;14 (3-4) :381-401.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
μ Opioid Receptor/MOR
Frequently Asked Questions
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