And1-IN-1
And1-IN-1 is a potent And1 inhibitor with an IC50 of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer[1].
Product Specifications
CAS Number
[2451028-69-4]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/and1-in-1.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 120 mg/mL (ultrasonic)
Smiles
OB1OCC2=CC(/C=C/C3=CC=C(Cl)C(Cl)=C3)=CC=C21
Molecular Formula
C15H11BCl2O2
Molecular Weight
304.96
References & Citations
[1]Li J, et al. Discovery and characterization of potent And-1 inhibitors for cancer treatment. Clin Transl Med. 2021 Dec;11 (12) :e627.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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