NSC745885

NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers[1][2].

Product Specifications

CAS Number

[4219-52-7]

UNSPSC

12352005

Target

Apoptosis; Histone Methyltransferase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc745885.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C2=O)C3=NSN=C3C=C1)C4=C2C=CC=C4

Molecular Formula

C14H6N2O2S

Molecular Weight

266.27

References & Citations

[1]Chen YW, et al.A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.PLoS One. 2014 Aug 15;9 (8) :e104703.|[2]Tang SH, et al. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo.Oncotarget. 2014 Nov 15;5 (21) :10342-55.