STAT3 ligand 5
STAT3 ligand 5 is a ligand for STAT3, that can be used as target protein ligand for synthesis of PROTAC degrader SD-436.
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-ligand-5.html
Smiles
O=C1[C@H](CN(CC[C@@H]2N1[C@@H](CC2)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CC3=CC=C(C(F)=C3)F)=O)=O)C(OC)=O)NC(C4=CC5=C(S4)C=CC(C(F)(P(O)(O)=O)F)=C5)=O
Molecular Formula
C36H39F4N6O12PS
Molecular Weight
886.76
References & Citations
[1]Xu R, et al., Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. J Med Chem. 2024 Nov 28;67 (22) :20495-20513.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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