Pergolide-d7 (mesylate)
Pergolide-d7 (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].
Product Specifications
Product Name Alternative
Pergolide methanesulfonate-d7; LY127809-d7
UNSPSC
12352005
Target
Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
[H][C@@]1(N(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C[C@H](CSC)C[C@@]12[H])CC3=CNC4=CC=CC2=C43.CS(=O)(O)=O
Molecular Formula
C20H23D7N2O3S2
Molecular Weight
417.64
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]S Franks, et al. Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia. Br Med J (Clin Res Ed) . 1983 Apr 9;286 (6372) :1177-9.|[3]Daniela Uberti, et al. Pergolide protects SH-SY5Y cells against neurodegeneration induced by H (2) O (2) . Eur J Pharmacol. 2002 Jan 2;434 (1-2) :17-20.|[4]Alin Ciobica, et al. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. J Physiol Biochem. 2012 Mar;68 (1) :59-69.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
D2 Receptor
Available Sizes
Frequently Asked Questions
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