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MZ82

Product Specifications

UNSPSC Description

MZ82, Ko 143 (HY-10010) derivative, is a ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor with the IC50 of ~23 nM. MZ82 not only shows greatly improved metabolic stability over Ko 143 (HY-10010) in liver microsomes but also in mice, and is able to penetrate into the brain[1].

Target Antigen

BCRP

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mz82.html

Smiles

O=C1N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CC(C)C)C4=C(C5=CC=C(OC)C=C5N4)CC31)=O

Molecular Weight

431.53

References & Citations

[1]Yu Q, et al. Modulation of ABCG2 Transporter Activity by Ko143 Derivatives. ACS Chem Biol. 2024 Nov 15;19(11):2304-2313.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-168572/MZ82-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-168572/

Clinical Information

No Development Reported

Curated Selection

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