Enpp-1-IN-20
Enpp-1-IN-20 (Compound 31) is an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor, with an IC50 of 0.09 nM. Enpp-1-IN-20 has strongest inhibitory activity in the cell-based assay, with an IC50 of 8.8 nM. Enpp-1-IN-20 has significant potency in both ENPP1 inhibition and STING pathway stimulation in vitro. Enpp-1-IN-20 can be used for the research of cancer[1].
Product Specifications
CAS Number
[3029600-37-8]
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; STING
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/enpp-1-in-20.html
Purity
98.06
Solubility
DMSO : 1.92 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)
Smiles
O=C1NC(N=CN=C2N3C[C@@]4([C@]([H])(C3)[C@H]4CCP(O)(O)=O)[H])=C2C=C1
Molecular Formula
C14H17N4O4P
Molecular Weight
336.28
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Magic™ Membrane Protein Human JAM2 (Junctional adhesion molecule 2) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, PaRoom Temperatureial (29-238aa)
PIP4K2A (Phosphatidylinositol-5-phosphate 4-kinase Type-2 alpha, 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha, Diphosphoinositide Kinase 2-alpha, PIP5KIII, Phosphatidylinositol-5-phosphate 4-kinase Type II alpha, PI(5)P 4-kinase Type II alpha, PIP4
PIP4K2A (Phosphatidylinositol-5-phosphate 4-kinase Type-2 alpha, 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha, Diphosphoinositide Kinase 2-alpha, PIP5KIII, Phosphatidylinositol-5-phosphate 4-kinase Type II alpha, PI(5)P 4-kinase Type II alpha, PIP4
