Orotic acid (zinc)

Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

Product Specifications

CAS Number

[68399-76-8]

Product Name Alternative

6-Carboxyuracil (zinc) ; Vitamin B13 (zinc)

UNSPSC

12352005

Target

Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/orotic-acid-zinc.html

Purity

99.84

Solubility

DMSO : 20 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)

Smiles

O=C(C(NC1=O)=CC(N1)=O)O.[0.5Zn]

Molecular Formula

C5H4N2O4Zn0.5

Molecular Weight

188.79

References & Citations

[1]Löffler M, et, al. Orotate (orotic acid) : An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids.|[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15.|[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110 (4) :816-21.