5-Chloro-2'-deoxyuridine
5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors.
Product Specifications
CAS Number
50-90-8
Product Name Alternative
5-Chlorodeoxyuridine; CldU
UNSPSC
12352005
Hazard Statement
H351
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-Chloro-2_acute_-deoxyuridine.html
Purity
99.97
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(Cl)=C2)=O)=O)O1
Molecular Formula
C9H11ClN2O5
Molecular Weight
262.65
Precautions
H351
References & Citations
[1]Kim CH, et al. Polymerase incorporation and miscoding properties of 5-chlorouracil. Chem Res Toxicol. 2010 Apr 19;23 (4) :740-8.|[2]Yuan CJ, et al. Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacol Biochem Behav. 2011 Nov;100 (1) :98-108.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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