5-Chloro-2'-deoxyuridine

5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors.

Product Specifications

CAS Number

[50-90-8]

Product Name Alternative

5-Chlorodeoxyuridine; CldU

UNSPSC

12352005

Hazard Statement

H351

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-Chloro-2_acute_-deoxyuridine.html

Purity

99.97

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(Cl)=C2)=O)=O)O1

Molecular Formula

C9H11ClN2O5

Molecular Weight

262.65

Precautions

H351

References & Citations

[1]Kim CH, et al. Polymerase incorporation and miscoding properties of 5-chlorouracil. Chem Res Toxicol. 2010 Apr 19;23 (4) :740-8.|[2]Yuan CJ, et al. Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacol Biochem Behav. 2011 Nov;100 (1) :98-108.