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Linvoseltamab

Linvoseltamab (REGN5458) is a bispecific T-cell engager (BiTE) antibody that specifically binds to B cell maturation antigen (BCMA) and CD3 of T cells, thereby directing T cells to multiple myeloma (MM) cells expressing BCMA and activating T cells to kill tumor cells. Linvoseltamab can be used in research of relapsed/refractory multiple myeloma (RRMM) [1][2][3].

Product Specifications

CAS Number

2408319-25-3

Product Name Alternative

REGN5458

UNSPSC

12352203

Target

CD3; TNF Receptor

Type

Inhibitory Antibodies

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/linvoseltamab.html

Purity

99.71

Solubility

10 mM in DMSO|H2O

Smiles

[Linvoseltamab]

Molecular Weight

(145.51 kDa)

References & Citations

[1]Lee H C, et al. LINKER-MM1 study: Linvoseltamab (REGN5458) in patients with relapsed/refractory multiple myeloma[J]. 2023.|[2]Linvoseltamab. IMGT/mAb-DB.|[3]DiLillo DJ, et al., A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells. Blood Adv. 2021 Mar 9;5 (5) :1291-1304.

Shipping Conditions

Dry Ice

Storage Conditions

Store at -80°C for 2 years

Scientific Category

Inhibitory Antibodies

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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