BC-1471
BC-1471 is a STAMBP deubiquitinase inhibitor with an IC50 of 0.33 μM. BC-1471 can inhibit the activity of the NALP7 inflammasome. BC-1471 has anti-inflammatory activity and can be used for the research of inflammatory diseases[1].
Product Specifications
CAS Number
[896683-84-4]
UNSPSC
12352005
Target
Caspase; Deubiquitinase; Interleukin Related
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bc-1471.html
Purity
99.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCC1OCCC1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
Molecular Formula
C27H32N4O4S
Molecular Weight
508.63
References & Citations
[1]Bednash JS, et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017 May 11;8:15203.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; IL-1
Available Sizes
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Cdc4 (FBXW7, F-box and WD repeat domain containing 7, AGO, Archipelago homolog, DKFZp686F23254, F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ11071, FLJ16457, h
Cdc4 (FBXW7, F-box and WD repeat domain containing 7, AGO, Archipelago homolog, DKFZp686F23254, F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ11071, FLJ16457, h
