Resveratrol-d4

Resveratrol-d4 is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

Product Specifications

CAS Number

[1089051-56-8]

Product Name Alternative

Trans-Resveratrol-d4; SRT501-d4

UNSPSC

12352005

Hazard Statement

H225, H350

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; Fungal; IKK; Isotope-Labeled Compounds; Keap1-Nrf2; Mitophagy; Sirtuin

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; NF-κB; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Purity

99.9

Solubility

DMF : ≥ 100mg/mL|DMSO : ≥ 50mg/mL|Ethanol : ≥ 50mg/mL

Smiles

OC1=CC(/C=C/C2=C([2H])C([2H])=C(O)C([2H])=C2[2H])=CC(O)=C1

Molecular Formula

C14H8D4O3

Molecular Weight

232.27

Precautions

H225, H350

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60 (5) :323-32.|[3]Lu R, et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179 (3) :297-304.|[4]Lee MH, et al. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009 Sep 15;69 (18) :7449-58.|[5]Du LL, et al. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr) . 2014 Apr;36 (2) :613-23.|[6]Smutny T, et al. Resveratrol as an inhibitor of pregnane X receptor (PXR) : another lesson in PXR antagonism. J Pharmacol Sci. 2014;126 (2) :177-8.|[7]Eun Nim Kim, et al. Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. Aging (Albany NY) . 2018 Jan; 10 (1) : 83–99.|[8]Huige Li, et al. Resveratrol and Vascular Function. Int J Mol Sci. 2019 Apr 30;20 (9) :2155.