Fluorescein-DBCO
Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Fluorescein-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
CAS Number
[2054339-00-1]
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
Dye Reagents
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fluorescein-dbco.html
Purity
96.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(NC4=CC=C(C5=C4)C6(OC5=O)C7=C(OC8=C6C=CC(O)=C8)C=C(O)C=C7)=S
Molecular Formula
C39H27N3O6S
Molecular Weight
665.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
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