CAIX Inhibitor S4

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively) . CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth[1].

Product Specifications

CAS Number

[1330061-67-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/caix-inhibitor-s4.html

Purity

99.04

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C)=CC(C)=C1)NC2=CC=C(C=C2)OS(=O)(N)=O

Molecular Formula

C15H17N3O4S

Molecular Weight

335.38

Precautions

H302, H315, H319

References & Citations

[1]Gieling RG, et, al. Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J Med Chem. 2012 Jun 14;55 (11) :5591-600.