2-Cyanopyrimidine
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].
Product Specifications
CAS Number
[14080-23-0]
UNSPSC
12352005
Hazard Statement
H301, H317
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-cyanopyrimidine.html
Purity
99.99
Solubility
DMSO : < 1 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
N#CC1=NC=CC=N1
Molecular Formula
C5H3N3
Molecular Weight
105.10
Precautions
H301, H317
References & Citations
[1]Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50 (4) :591-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin K
Available Sizes
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