F-1

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].

Product Specifications

CAS Number

[2244775-31-1]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; ROS Kinase

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/f-1.html

Concentration

10mM

Purity

98.03

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 65°C)

Smiles

O=S(NC1=C(NC2=NC(NC3=C(OC)N=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)C=CC=C1)(C)=O

Molecular Formula

C22H27ClN8O3S

Molecular Weight

519.02

References & Citations

[1]Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333.