(Sar1, Ile4,8) -Angiotensin II

(Sar1, Ile4,8) -Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1, Ile4,8) -Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1, Ile4,8) -Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β[1].

Product Specifications

CAS Number

[185461-45-4]

UNSPSC

12352209

Target

Angiotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sar1-ile4-8-angiotensin-ii.html

Purity

99.75

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CNCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CN=CN1)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C43H75N13O9

Molecular Weight

918.14

References & Citations

[1]Sanni SJ, et al. [Sar1, Ile4, Ile8]-angiotensin II Potentiates Insulin Receptor Signalling and Glycogen Synthesis in Hepatocytes. Basic Clin Pharmacol Toxicol. 2018 May;122 (5) :460-469.