BMS-593214

BMS-593214 is an active site-directed factor (F) VIIa inhibitor. BMS-593214 shows antithrombotic and antihaemostatic properties. BMS-593214 is a direct competitive inhibitor of human FVIIa and a non-competitive inhibitor of Viia-activated substrate FX. BMS-593214 prevents electroinduced carotid artery thrombosis (AT) and wire induced vena cava thrombosis (VT) [1].

Product Specifications

CAS Number

[1004551-40-9]

Product Name Alternative

GNF-Pf-1127

UNSPSC

12352005

Target

Factor VIIa

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bms-593214.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(C=C1)C2=CC(O)=C(C=C2[C@@H]3NC4=C([C@@]5([C@]3(CC6=C5C=CC=C6)[H])[H])C=C(C=C4)C(N)=N)OC

Molecular Formula

C31H27N3O4

Molecular Weight

505.56

References & Citations

[1]Wong PC, et al. BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies. Thromb Haemost. 2010 Aug;104 (2) :261-9.