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HTH-01-091

Product Specifications

UNSPSC Description

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research[1].

Target Antigen

CDK; DYRK; GSK-3; MELK; mTOR; Pim; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hth-01-091.html

Purity

98.64

Solubility

DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=C1N([C@H]2CC[C@H](CN(C)C)CC2)C3=C(CN1)C=NC4=CC=C(C5=CC(Cl)=C(O)C(Cl)=C5)C=C34

Molecular Weight

499.43

References & Citations

[1]Huang HT, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-122665/HTH-01-091-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-122665/HTH-01-091-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2000209-42-5

Available Sizes

Curated Selection

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