Ebselen oxide

Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM) [1][2][3].

Product Specifications

CAS Number

[104473-83-8]

UNSPSC

12352005

Hazard Statement

H301+H331-H315-H335-H373-H410

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ebselen-oxide.html

Purity

98.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

O=[Se]1N(C(C2=C1C=CC=C2)=O)C3=CC=CC=C3

Molecular Formula

C13H9NO2Se

Molecular Weight

290.18

Precautions

P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P403+P233-P405-P501

References & Citations

[1]Lieberman OJ, et al. High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases. ACS Chem Biol. 2014;9 (1) :183-192. |[2]Kim SK, et al. Inhibition of Pseudomonas aeruginosa Alginate Synthesis by Ebselen Oxide and Its Analogues. ACS Infect Dis. 2021;7 (6) :1713-1726. |[3]Wang Y, et al. Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs. Drug Des Devel Ther. 2017;11:1369-1382. Published 2017 May 2.