CAD204520

CAD204520, a SERCA inhibitor (IC50 = 0.34 μM), targets mutated over wild type NOTCH1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL) . CAD204520 can be used for T-ALL and MCL research[1].

Product Specifications

CAS Number

[2682205-20-3]

UNSPSC

12352005

Target

Calcium Channel; Notch

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cad204520.html

Purity

99.22

Smiles

CCCC(C(C=CC(OC(F)(F)F)=C1)=C1N2)=C2C3N(CCN4CCOCC4)CCCC3

Molecular Formula

C23H32F3N3O2

Molecular Weight

439.51

References & Citations

[1]Matteo Marchesini, et al. Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia. Cell Chem Biol. 2020 Jun 18;27 (6) :678-697.e13.